Comprehensive Snake Venomics of the Okinawa Habu Pit Viper, Protobothrops flavoviridis, by Complementary Mass Spectrometry-Guided Approaches
作者: Maik DammBenjamin-Florian HempelAyse NalbantsoyRoderich D. SüssmuthJean-Marc Sabatier
作者单位: 1Institut für Chemie, Technische Universität Berlin, 10623 Berlin, Germany; maik.damm@tu-berlin.de (M.D.); benjamin.hempel@chem.tu-berlin.de (B.-F.H.)
2Department of Bioengineering, Ege University, 35100 Izmir, Turkey; analbantsoy@gmail.com
刊名: Molecules, 2018, Vol.23 (8)
来源数据库: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/molecules23081893
关键词: Snake venomicsViperidaeProtobothrops flavoviridisHabu pit viperBottom-upTop-downBPPTripeptide metalloprotease inhibitorCytotoxicity
原始语种摘要: The Asian world is home to a multitude of venomous and dangerous snakes, which are used to induce various medical effects in the preparation of traditional snake tinctures and alcoholics, like the Japanese snake wine, named Habushu. The aim of this work was to perform the first quantitative proteomic analysis of the Protobothrops flavoviridis pit viper venom. Accordingly, the venom was analyzed by complimentary bottom-up and top-down mass spectrometry techniques. The mass spectrometry-based snake venomics approach revealed that more than half of the venom is composed of different phospholipases A2 (PLA2). The combination of this approach and an intact mass profiling led to the identification of the three main Habu PLA2s. Furthermore, nearly one-third of the total venom consists of snake...
全文获取路径: MDPI  (合作)
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影响因子:2.428 (2012)

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关键词翻译
关键词翻译
  • snake 
  • viper 蝮蛇
  • venom 毒物
  • spectrometry 光谱测定
  • highest 最高的
  • human 人的
  • nucleotidase 核苷酸酶
  • complimentary 免费赠送的
  • bottom 底壁
  • lectin 植物凝血素