Comparative Venomics of the Vipera ammodytes transcaucasiana and Vipera ammodytes montandoni from Turkey Provides Insights into Kinship
作者: Benjamin-Florian HempelMaik DammBayram GöçmenMert KarisMehmet Anıl OguzAyse NalbantsoyRoderich D. Süssmuth
作者单位: 1Department of Chemistry, Technische Universität Berlin, 10623 Berlin, Germany; (B.-F.H.); (M.D.)
2Department of Biology, Ege University, 35100 Izmir, Turkey; (B.G.); (M. K.); (M.A.O.)
3Department of Bioengineering, Ege University, 35100 Izmir, Turkey
刊名: Toxins, 2018, Vol.10 (1)
来源数据库: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/toxins10010023
关键词: ViperidaeVipera ammodytesTranscaucasian Nose-horned ViperTransdanubian Sand ViperSnake venomicsIntact mass profilingTripeptide metalloprotease inhibitorCytotoxicityThe detailed characterization and comparison of the venom proteome Vipera ammodytes transcaucasiana and Vipera ammodytes montandoni showed an impressive matching of the venom compositionWhich could help to overcome the question of the taxonomic status of Vipera ammodytestranscaucasiana. Additional bioactivity screenings against
原始语种摘要: The Nose-horned Viper (Vipera ammodytes) is one of the most widespread and venomous snakes in Europe, which causes high frequent snakebite accidents. The first comprehensive venom characterization of the regional endemic Transcaucasian Nose-horned Viper (Vipera ammodytes transcaucasiana) and the Transdanubian Sand Viper (Vipera ammodytes montandoni) is reported employing a combination of intact mass profiling and bottom-up proteomics. The bottom-up analysis of both subspecies identified the major snake protein families of viper venoms. Furthermore, intact mass profiling revealed the presence of two tripeptidic metalloprotease inhibitors and their precursors. While previous reports applied multivariate analysis techniques to clarify the taxonomic status of the subspecies, an accurate...
全文获取路径: MDPI 
影响因子:2.129 (2012)

  • horned 装角于...
  • subspecies 亚种
  • snakebite 毒蛇咬伤
  • screenings 筛屑
  • viper 蝮蛇
  • cancerous 癌性的
  • bottom 底壁
  • slightly 轻徽地
  • bioactivity 生物活性
  • intact 完整的