Short-Term Betanin Intake Reduces Oxidative Stress in Wistar Rats
| 作者： | Davi Vieira Teixeira da Silva, Aline D’Avila Pereira, Gilson Teles Boaventura, Roberto Stefan de Almeida Ribeiro, Maurício Afonso Verícimo, Carla Eponina de Carvalho-Pinto, Diego dos Santos Baião, Eduardo Mere Del Aguila, Vania M. Flosi Paschoalin |
| 作者单位： |
1Instituto de Química, Universidade Federal do Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Rio de Janeiro 21941-909, RJ, Brazil 2Departamento de Nutrição e Dietética, Universidade Federal Fluminense, Niterói 24020-140, Brazil 3Departamento de Imunobiologia, Universidade Federal Fluminense, Niterói 24020-150, Brazil |
| 刊名： | Nutrients, 2019, Vol.11 (9) |
| 来源数据库： | Multidisciplinary Digital Publishing Institute |
| DOI： | 10.3390/nu11091978 |
| 关键词： | Beetroot; Hyperlipidemia; Lipid peroxidation; Oxidative stress; Antioxidant activity; Hepatic damage reversal; |
| 原始语种摘要： | Oxidative stress is a common condition described in risk factors for cardiovascular disease. Betanin, a bioactive pigment from red beetroot demonstrates anti-inflammatory and antioxidant properties. The main aim of this study was to evaluate the short-term intake of betanin against oxidative stress in a rodent model, a common condition described in several risk factors for cardiovascular disease. Oxidative stress was induced in Wistar rats by a hyperlipidemic diet for 60 days, followed by betanin administration (20 mg·kg−1) through oral gavage for 20 days. Plasma biochemical parameters and antioxidant enzyme activities were evaluated. Lipid peroxidation and histopathological changes were determined in the liver. The hyperlipidemic diet caused hyperglycemia, hyperinsulinemia, insulin... |
