A Novel Combination of Wheat Peptides and Fucoidan Attenuates Ethanol-Induced Gastric Mucosal Damage through Anti-Oxidant, Anti-Inflammatory, and Pro-Survival Mechanisms
作者: Juntao KanMolly HoodCharlie BurnsJeff ScholtenJennifer ChuangFeng TianXingchang PanJun DuMin Gui
作者单位: 1Nutrilite Health Institute, 720 Cailun Road, Shanghai 201203, China; junot.kan@Amway.com (J.K.); fred.tian@Amway.com (F.T.)
2Nutrilite Health Institute, 7575 East Fulton Avenue, Ada, MI 49355, USA; molly.hood@Amway.com (M.H.); charlie.burns@Amway.com (C.B.); jeff.scholten@Amway.com (J.S.)
3Nutrilite Health Institute, 5600 Beach Boulevard, Buena Park, CA 90621, USA; jennifer.chuang@Amway.com
4China National Research Institute of Food and Fermentation Industries, 24 Jiuxianqiao Middle Road, Beijing 100015, China; nutripan@163.com
刊名: Nutrients, 2017, Vol.9 (9)
来源数据库: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/nu9090978
关键词: gastric mucosal damagewheat peptidesfucoidananti-oxidantanti-inflammationpro-survival
原始语种摘要: Gastritis or peptic ulcer is believed to affect about half of people worldwide. Traditional medications can lead to adverse effects, therefore, alternative nutritional strategies are needed to prevent the development of gastric mucosal damage. A novel combination of two food-grade ingredients, wheat peptides and fucoidan (WPF), was prepared to treat male Sprague Dawley rats for 30 days before gastric mucosal damage was induced by oral administration of ethanol. The serum levels of biomarkers were determined by enzyme-linked immunosorbent assay. Biomarkers in stomach tissue were analyzed using immunohistochemistry. In addition, human gastric epithelial cell line (GES-1) was used to investigate protein expression by Western blot. WPF could attenuate ethanol-induced gastric mucosal damage in...
全文获取路径: MDPI  (合作)
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影响因子:2.072 (2012)

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关键词翻译
关键词翻译
  • induced 感应的
  • gastric 胃的
  • mucosal 粘膜的
  • attenuate 衰减
  • ethanol 乙醇
  • ulcer 溃疡
  • superoxide 过氧化物
  • fucoidan 岩藻依聚糖
  • stomach 
  • peptic 胃酶的