Modern Methods of Sample Preparation for the Analysis of Oxylipins in Biological Samples
作者: Ivan LiakhAlicja PakietTomasz SledzinskiAdriana MikaNuno Neng
作者单位: 1Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland; (I.L.); (T.S.)
2Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland;
刊名: Molecules, 2019, Vol.24 (8)
来源数据库: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/molecules24081639
关键词: Sample preparationOxylipinsProtein precipitationLiquid–liquid extractionSolid-phase extractionBiological samples
原始语种摘要: Oxylipins are potent lipid mediators derived from polyunsaturated fatty acids, which play important roles in various biological processes. Being important regulators and/or markers of a wide range of normal and pathological processes, oxylipins are becoming a popular subject of research; however, the low stability and often very low concentration of oxylipins in samples are a significant challenge for authors and continuous improvement is required in both the extraction and analysis techniques. In recent years, the study of oxylipins has been directly related to the development of new technological platforms based on mass spectrometry (LC–MS/MS and gas chromatography–mass spectrometry (GC–MS)/MS), as well as the improvement in methods for the extraction of oxylipins from biological...
全文获取路径: MDPI 
影响因子:2.428 (2012)

  • extraction 提取
  • liquid 液体
  • improvement 改良
  • biological 生物学的
  • precipitation 沉淀
  • based 基于
  • spectrometry 光谱测定
  • systematize 系统化
  • phase 相位
  • concentration 浓度