Dasotraline: ’New kid on the Bloc
作者: Pankhuree Vandana
刊名: Journal of Drug Abuse, 2019, Vol.5 (2)
来源数据库: Insight Medical Publishing
关键词: DasotralineADHDPharmacokineticsProof of concept trialMisuse of stimulants
原始语种摘要: Attention Deficit Hyperactivity Disorder is a common neuro developmental disorder that can cause significant academic, interpersonal and adaptive impairments. Despite the development of several pharmacological options in last few years, search for an agent that is efficacious, has sustained clinical effects and without risk of abuse, continues. The need for such as agent is particularly critical considering the current opioid crisis. Sunovion Pharmaceuticals recently seeked FDA approval for one such agent Dasotraline which is a dopamine, serotonin and nor epinephrine reuptake inhibitor after preliminary trials established efficacy in adults and children with ADHD and Binge eating disorder in adult. We conducted a thorough review of the preclinical and clinical trials of this drug and used...
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  • reuptake 再摄取
  • serotonin 血清素
  • developmental 试验性的
  • disorder 无序
  • dopamine 多巴胺
  • abuse 滥用
  • epinephrine 肾上腺素
  • preclinical 临证前期的
  • efficacy 效验
  • efficacious 有效