We have investigated the dependence of the physical properties and biological activity of solid, soft and liquid pharmaceutical products and medical devices from mechanical and physical-chemical factors of local interaction with the body of a living person. Shows a significant dependence of the physical properties of the products and advanced materials from such factors as length of interaction, the magnitude of absolute and relative pressure, mass, relative, specific gravity, pH (acidity or alkalinity), concentration of ingredients, the osmotic activity and the degree of saturation of the gases. It was found that interaction with certain parts of the human body changes the properties of many modern pharmaceutical products and medical devices. Found that this is due to the... physical-chemical factors of local interaction. It is shown that pronounced changes in the physical-chemical properties of hard, soft and/or liquid materials from which they are made, by a certain value in one direction or another from the physical-chemical characteristics of tissues of the human body, physically in contact with them, are able to give these materials new properties. Discovered that medical devices, characterized by its temperature, gas composition, osmotic and/or acid activity of the relevant characteristics of body parts that come in contact with them, change their state, the stronger, the greater the difference in their physical-chemical activity and the longer the continuous interaction. In this regard, there’s an assumption that targeted changes in the physical and chemical characteristics of the standard (“old”) materials (i.e., known compounds), which underlie the production of products in solid and liquid state allows to obtain “new” design and materials. It is shown that giving old materials new physical-chemical properties and their use for the production of tablets and solutions can turn even very “old” drugs in a very “young” (in fact, even very fashionable) and new drugs with unprecedented (fantastic) pharmacological activity and with novel mechanisms of action.