Keigairengyoto, a traditional Japanese medicine, promotes bacterial clearance by activating innate immune cells in mouse cutaneous infection models
作者: Junichi Koseki, Atsushi Kaneko, Yosuke Matsubara, Kyoji Sekiguchi, Satomi Ebihara, Setsuya Aiba, Kenshi Yamasaki
刊名: Trends in Immunotherapy, 2017, Vol.1 (1)
来源数据库: EnPress Publisher
DOI: 10.24294/ti.v1.i1.31
关键词: KampoPhagocytosisResident macrophagesNeutrophilsStaphylococcus aureusFlavonoid glucuronideSkin
原始语种摘要: Prompt elimination of pathogens including bacteria and dead cells prevents the expansion of secondary and prolonged inflammations and tissue damage. Keigairengyoto (KRT) is a traditional Japanese medicine prescribed for dermatoses such as purulent inflammations. Our aim is to clarify the actions of KRT in bacterial clearance and to examine the cell-kinetic profiles of phagocytes. In a mouse cutaneous infection model using living Staphylococcus aureus, KRT drastically reduced the number of bacteria in the infection sites. To evaluate the bacterial clearance, pseudo-infection was induced in mouse ears by intradermal injection of FITC-conjugated dead S. aureus. Biochemical and histological examinations revealed that KRT promoted bacterial clearance at 6 and 24 h post-injection. The numbers...
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  • bacterial 细菌的
  • mouse 小鼠
  • numbers 数目
  • clearance 间隙
  • evaluate 求...的值
  • infection 感染
  • traditional 传统
  • fluorescent 萤光的
  • medicine 
  • Japanese 日本人日语日本的