Exosomemediated immune regulation and its clinical application
作者: Naohiro Seo
刊名: Trends in Immunotherapy, 2018, Vol.2 (1)
来源数据库: EnPress Publisher
DOI: 10.24294/ti.v2.i1.433
关键词: CD8+ T cellExosomeExtracellular vesicleMesenchymal cellTumor metastasis
原始语种摘要: Immune system is a precise mechanism for maintenance of homeostasis by lymphocyte-mediated elimination of extracellular and intercellular pathogens, and abnormal cells in cytokine-, chemokine-, antibody-, and cytotoxic granule-dependent manners. Extracellular vesicles, e.g. exosomes, released from multivesicular endosome in immune cells have been known to be a part of the immune system. Exosomes released by antigen-presenting cells (APCs) such as macrophages and dendritic cells (DCs) regulate natural killer (NK) cells, CD8+ T cells (Cytotoxic T lymphocytes [CTLs]), and CD4+ T cells (Th cells) including Th1, Th2, and regulatory T (Treg) cells. In the anti-tumor immune system, NK cells and CTLs are mainly involved in the elimination of tumor cells by direct interaction. Recently, we...
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  • immune 免疫的
  • cells 麻风细胞
  • endosome 核内体
  • lymphocyte 淋巴细胞
  • vesicle 气泡
  • cytotoxic 细胞毒素的
  • dendritic 师状的
  • regulatory 控制的
  • antibody 抗体
  • regulation