Background: The ingrown toenail results from a painful conflict between the nail plate and the adjacent soft parts.Material and methods: We conducted a prospective, comparative trial of the long-term efficacy of two methods:phenolization (88%) and matricolysis by trichloroacetic acid (TCA) (100%). Adult, consenting patients with ingrowntoenails were alternately allocated into two treatment, to receive either 88% phenol or 100% TCA chemical matricectomy.The patients as well as the statistician were blinded to the agent being used. Post-procedure follow-up evaluated medianduration of pain, discharge, and healing along with recurrence, if any, in both the groups. The group wise data wasstatistically analyzed. Results: On comparing the two groups, pain lasted 9.34 days in the TCA group and... 18.62 daysin the phenol group, this difference was not statistically significant (P = 0.202). The tissue condition took 9.30 daysto normalize in the the TCA group, while it took 17.63 days to normalize in the phenol group. This difference wasfound to be statistically significant (P < 0.007). The aesthetic result and the cost of the care were similar in the 2groups. Conclusion: Chemical matricectomy using TCA is as efficacious as phenolisation, with the advantage of fastertissue normalization.