This study provides an analysis of the cultural and empirical determinants of county level obesity rates in the United States and advances the discourse on the intergenerational transmission of culture with respect to food choices, preparation, and consumption. This study extends the theoretical framework to include the intersectionality of race, gender, location, household and lifestyle, all of which contribute to an overlapping and interdependent system of food inequality. An ordinary least squares regression model captures the attributes of counties that plausibly govern the variation in obesity rates across counties and regions. The principal finding is that African American percentage, rural location, limited access to healthy food options, unemployment and the percentage of single... parent households are positively and significantly associated with county obesity rates. The median household income, percentage of residents with some college education, and access to exercise opportunities are significantly related to lower levels of obesity. Policy implications of the results are discussed.