Pulse pressure is the result of the periodicity of cardiaccontraction and the nature of arterial circulation. Pulsepressure is affected by age, gender, height, heart rate,cholesterol, diabetes, hypertension, homocysteine, pulsepressure amplification, atherosclerosis, arteriosclerosis,coronary artery perfusion and other factors. As anindependent risk factor for the occurrence of coronaryartery stenosis, coronary heart disease, myocardialinfarction and cerebral apoplexy, pulse pressure is evenmore valuable than systolic and diastolic blood pressure inpredicting atherosclerosis, cardiovascular andcerebrovascular diseases and death. Previous studies haveconfirmed that pulse pressure is closely linked to geneticpolymorphism of multiple genes. Some scholars have reportedthat pulse pressure is... significantly correlated with theSNPs of angiotensin converting enzyme (ACE) gene,endothelial nitric oxide (eNOS) gene and dopamine receptorgene, etc. The change of pulse pressure is affected bymultiple SNPs.