Article: Expression of IGF-IR in Breast Cancer tissue before and after Neoadjuvant Chemotherapy
作者: Ximing Shen Dongxia Wu Xinxin He Gengbiao Chen Yunjie Zeng
刊名: Cancer Cell Research, 2014, Vol.1 (3), pp.70-75
来源数据库: Guoyu exquisite culture Co., Ltd
原始语种摘要: Neoadjuvant chemotherapy (NAC) is a common therapeutic schedule in treatment of breast cancer. In order to discover the mechanism of IGF-IR in breast cancer tissue and its influence on cell proliferation and CAM angiogenesis and NAC effect. 160 breast cancer patients in II and III period were selected and tested the expression of IGF-IR. All the patients were diagnosed according to specimen taken with needle biopsy and treated with NAC (Duoxitasai, epirubicin and cyclophosphamide) for 2 months, had mastectomy and tested expression of IGF-IR. The results showed that positive expression rate of IGF-IR in breast cancer patients were73.125% and the expression of IGF-IR is closely related with the periods of tumor and Axillary node metastases (P=0.01) but not related with tumor size (P=0.21)....
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  • breast 胸部
  • mastectomy 乳房切除
  • epirubicin 表柔比星
  • Article 物品
  • chemotherapy 化学疗法
  • expression 表示
  • angiogenesis 血管生成
  • Cancer 巨蟹座
  • expressed 榨出的
  • therapeutic 治疗的