Ximing Shen, Dongxia Wu, Xinxin He, Gengbiao Chen, Yunjie Zeng
||Cancer Cell Research, 2014, Vol.1 (3), pp.70-75
||Guoyu exquisite culture Co., Ltd
Neoadjuvant chemotherapy (NAC) is a common therapeutic schedule in treatment of breast cancer. In order to discover the mechanism of IGF-IR in breast cancer tissue and its influence on cell proliferation and CAM angiogenesis and NAC effect. 160 breast cancer patients in II and III period were selected and tested the expression of IGF-IR. All the patients were diagnosed according to specimen taken with needle biopsy and treated with NAC (Duoxitasai, epirubicin and cyclophosphamide) for 2 months, had mastectomy and tested expression of IGF-IR. The results showed that positive expression rate of IGF-IR in breast cancer patients were73.125% and the expression of IGF-IR is closely related with the periods of tumor and Axillary node metastases (P=0.01) but not related with tumor size (P=0.21).... After treatment, IGF-IR in 65 patients had changed from high-expression to low expression (P=0.001) and negative conversion rate was 55.56%. Total effective rate of patients whose IGF-IR is positively expressed was 84.62%, which is obviously lower than that of patients with IGF-IR negatively expressed (P=0.035). IGF-IR before treatment is closely related to VEGF, MVD and ki-67 (P=0.001). NAC can partly inhibit expression of IGF-IR to inhibit tumor growth and treatment with IGF-IR can effectively inhibit proliferation of breast cancer cells and CAM angiogenesis ability.