Effect of API on Powder Flowability, Direct Compression and Properties of Orally Disintegrating Tablets: A Preformulation Study
作者: M. J. NachajskiA. BazelaM. ZarzyckaA. BroszczykA. Kolba and M. K. Kolodziejczyk
刊名: Indian Journal of Pharmaceutical Sciences, 2019, Vol.81 (3)
来源数据库: Indian Pharmaceutical Association
关键词: Orally disintegrating tabletsActive pharmaceutical ingredientFlowabilityWettability
原始语种摘要: The aim of the study was to analyze the effect of the active pharmaceutical ingredient on the flowability of the powder and properties of tablets prepared using direct compression method. Each analyzed formulation contained one model active pharmaceutical ingredient, diphenhydramine, ketoprofen or loratadine. Granulometric properties of the powder formulations were determined based on bulk density prior and after compression, Hausner ratio, Carr index and angle of repose values. The analysis of manufactured tablets included determination of their hardness, thickness, mass, disintegration time, wettability, contact angle and swelling index values. The preformulation study confirmed that characteristics of the active pharmaceutical ingredient might have modified physicochemical properties...
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影响因子:0.338 (2012)

  • tablets 平片体
  • preformulation 处方设计
  • pharmaceutical 
  • disintegrating 破碎
  • ketoprofen 酮洛芬
  • ingredient 拼份
  • compression 压缩
  • flowability 怜性
  • properties 道具
  • values 价值观