Long-acting Oral Formulation of Doxycycline: In vitro-in vivo Correlation Studies
作者: Sara M. ArciniegasMaria J. BernadS. C. CarlinI. Juarez and Dinorah Vargas
刊名: Indian Journal of Pharmaceutical Sciences, 2019, Vol.81 (4)
来源数据库: Indian Pharmaceutical Association
关键词: DissolutionBioavailabilityIn vitro modelsOral drug deliveryPolymeric drugs
原始语种摘要: The aim of this study was to establish and validate an in vitro-in vivo correlation that could predict the bioavailability of 4 oral long-acting formulations of doxycycline hyclate, acrylic acid and polymethacrylate matrices prepared using various proportions of doxycycline:acrylic acid:polymethacrylate for formulation 1 (1:0.25:0.0035), formulation 2 (1:0.5:0.0075), formulation 3 (1:1:0.015) and formulation 4 (1:2:0.0225) and a sample of doxycycline without excipients. In vitro dissolution profiles were obtained in phosphate buffer and hydrochloric acid media, which were fitted to several mathematical models. Plasma concentrations were obtained from 48 healthy dogs to achieve in vivo profiles. Therapeutic concentrations were observed for 60 h for formulation 1 and 4, 48 h for formulation...
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影响因子:0.338 (2012)

  • formulation 配方
  • acting 动作
  • doxycycline 强力霉素
  • concentration 浓度
  • correlation 对比
  • vitro 体外
  • dissolution 溶解
  • fitted 配合的
  • observed 观察到的
  • point