Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease.
作者: Walker Michael PLaferla Frank MOddo Salvador SBrewer Gregory J
作者单位: 1Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, 62794-9626, USA.
刊名: Age, 2013
来源数据库: PubMed Journal
DOI: 10.1007/s11357-011-9375-5
原始语种摘要: With aging and Alzheimer's disease (AD), there is an increased sensitivity to stress along with declines in the memory-associated neurotrophin brain-derived neurotrophic factor in AD. We have replicated this aging phenotype in cultured neurons from aged mice despite being grown in the same environmental conditions as young neurons. This led us to hypothesize that age-related differences in epigenetic acetylation and methylation of histones are associated with age-related gene regulation. We cultured hippocampal/cortical neurons from the 3xTg-AD mouse model and from non-transgenic mice to quantify single cell acetylation and methylation levels across the life span. In non-transgenic neurons, H3 acetylation was unchanged with age, while H4 acetylation decreased with age of the donor....
全文获取路径: PubMed  (合作)
影响因子:4.084 (2012)

  • expression 表示
  • histone 组蛋白
  • mouse 小鼠
  • acetylation 乙酰化
  • epigenetic 后成的
  • aging 老化
  • repressive 压制
  • amplified verification扩大核查
  • increased 增加
  • higher