The role of the T cell in age-related inflammation.
作者: Macaulay RichardAkbar Arne NHenson Sian M
作者单位: 1Division of Infection and Immunity, Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, UK.
刊名: Age, 2013
来源数据库: PubMed Journal
DOI: 10.1007/s11357-012-9381-2
原始语种摘要: Ageing is accompanied by alterations to T-cell immunity and also by a low-grade chronic inflammatory state termed inflammaging. The significance of these phenomena is highlighted by their being predictors of earlier mortality. We have recently published that the proinflammatory cytokine TNFα is a strong inducer of CD4(+) T-cell senescence and T-cell differentiation, adding to the growing body of literature implicating proinflammatory molecules in mediating these critical age-related T-cell alterations. Moreover, the inflammatory process is also being increasingly implicated in the pathogenesis of many common and severe age-related diseases, including cancer, cardiovascular diseases and type 2 diabetes. Furthermore, major age-related risk factors for poor health, such as obesity, stress...
全文获取路径: PubMed  (合作)
影响因子:4.084 (2012)

  • inflammation 炎症
  • related 有关的
  • influenza 列性感冒
  • crucial 有决定性的
  • inflammatory 激怒的
  • cytokine 细胞因子
  • being 
  • earlier 早期的
  • immunity 免疫
  • underpinning 加固基础