Survivin expression increases during aging and enhances the resistance of aged human fibroblasts to genotoxic stress.
作者: Al-Khalaf Huda HAboussekhra Abdelilah
作者单位: 1Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, MBC #03-66, P.O. Box 3354, Riyadh, 11211, Saudi Arabia.
刊名: Age, 2013
来源数据库: PubMed Journal
DOI: 10.1007/s11357-011-9378-2
原始语种摘要: Survivin, an important anti-apoptotic protein, is highly expressed in most cancers, which generally arise in cells of older individuals. We have shown here accumulation of survivin and phospho-survivin in aged normal human skin fibroblasts and mice organs. This age-related accumulation of survivin was due to protein stabilization through association with the molecular chaperone Hsp90 protein, which was also up-regulated during aging. Interestingly, Hsp90 binds preferentially to phospho-survivin, which explains its higher stability. In addition, we provide clear evidence that aged cells exhibit apoptosis resistance when challenged with UV light, cisplatin, γ-rays or H(2)O(2) as compared to their younger counterparts. In response to γ-rays and H(2)O(2), the levels of Bcl-2 and both forms of...
全文获取路径: PubMed  (合作)
影响因子:4.084 (2012)

  • expression 表示
  • aging 老化
  • organs 男生殖器
  • human 人的
  • increased 增加
  • exhibit 展出
  • protein 蛋白质
  • stabilization 稳定
  • expressed 榨出的
  • addition 添加