Activation of the transcription factor Nrf2 in macrophages, Caco-2 cells and intact human gut tissue by Maillard reaction products and coffee.
作者: Sauer TanjaRaithel MartinKressel JürgenMünch GeraldPischetsrieder Monika
作者单位: 1Department of Chemistry and Pharmacy, Food Chemistry, Emil Fischer Center, Friedrich-Alexander University, Schuhstr. 19, 91052, Erlangen, Germany.
刊名: Amino Acids, 2013
来源数据库: PubMed Journal
DOI: 10.1007/s00726-012-1222-1
原始语种摘要: In addition to direct antioxidative effects, Maillard reaction products (MRPs) could increase the antioxidative capacity of cells through the induction of cytoprotective enzymes. Since many of those enzymes are regulated by the transcription factor Nrf2, the effect of MRPs on nuclear translocation of Nrf2 in macrophages and Caco-2 cells was investigated. Stimulation of both cell types by MRPs showed a concentration-dependent significant increase in nuclear translocation of Nrf2 up to fivefold after short-term (2 h) and up to 50-fold after long-term treatment (24 h). In intact human gut tissue, nuclear translocation of Nrf2 was significantly twofold increased after short-term incubation. To study the activation mechanisms, macrophages and Caco-2 cells were stimulated with MRPs in the...
全文获取路径: PubMed  (合作)
影响因子:3.914 (2012)

  • intact 完整的
  • tissue 组织
  • coffee 咖啡
  • macrophages 巨噬细胞
  • increased 增加
  • incubation 孵化
  • catalase 过氧化氢酶
  • reaction 反酌
  • products 制品
  • transcription 地名转写