The Société Française d'Oncologie Pédiatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia.
作者: Patte CAuperin AMichon JBehrendt HLeverger GFrappaz DLutz PCoze CPerel YRaphaël MTerrier-Lacombe M J
作者单位: 1Pediatrics Department, Institut Gustave Roussy, Rue Camille Desmoulins, 94805 Villejuif Cedex, France. patte@igr.fr
刊名: Blood, 2001, Vol.97 (11), pp.3370-9
来源数据库: PubMed Journal
原始语种摘要: This study was undertaken to show that a high survival rate can be obtained in B-cell (Burkitt and large B-cell) lymphoma and L3 leukemia with multiagent chemotherapy adapted to the tumor burden (stage, resection status, percentage of blasts in bone marrow, and central nervous system [CNS] involvement) and early response to chemotherapy, to investigate actual prognostic factors, and to see if large B-cell lymphoma can be treated with the same regimen as Burkitt lymphoma. Patients were classified into 3 risk groups. Group A (resected stage I and abdominal stage II) received 2 courses of vincristine, cyclophosphamide, doxorubicin, and prednisone. Group B (patients not eligible for groups A or C) received 5 courses of chemotherapy with, in addition, high-dose methotrexate, 3 g/m(2) over 3...
全文获取路径: PubMed  (合作)
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关键词翻译
关键词翻译
  • chemotherapy 化学疗法
  • leukemia 白血病
  • burden 负担
  • tailored 简明的
  • lymphoma 淋巴瘤
  • unselected 未经过选择的
  • cytarabine 阿糖胞苷
  • survival 生存
  • methotrexate 氨甲喋呤
  • response 响应