EZH2 Expression in Naturally Occurring Canine Tumors.
作者: Choi Hyun-JiLee Han-ByulPark Hyun-KyuCho Sung-MinHan Hyo-JeongLee Sang-JoonLee Ji-YoungNam Su-JeongCho Eun-HoSon Woo-Chan
作者单位: 1University of Ulsan College of Medicine, Asan Institute for Life Sciences, and Department of Pathology, Asan Medical Center, Seoul, Korea.
2University of Ulsan College of Medicine, Asa
刊名: Comparative medicine, 2019, Vol.68 (2), pp.148-155
来源数据库: PubMed Journal
原始语种摘要: Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in various normal and tumorous dog tissues and compared these patterns with those of the corresponding human tissues. Immunohistochemical analysis showed positive staining for EZH2 in 76 of 82 cases of canine tumors, whereas low or negligible staining occurred in normal tissues and other canine tumors, including hepatocellular adenoma and lipoma. In particular, canine lymphoma, melanoma, basal cell tumors, squamous cell carcinoma, and prostate cancer all show EZH2 overexpression, as do their human counterparts. Given...
全文获取路径: PubMed  (合作)
影响因子:1.12 (2012)

  • tumorous 肿的
  • hepatocellular 肝细胞性的
  • lymphoma 淋巴瘤
  • squamous 具鳞的
  • adenoma 腺瘤
  • carcinoma 癌症
  • melanoma 黑瘤
  • staining 染色
  • aggressiveness 侵蚀性
  • normal 法线