A functional promoter polymorphism of IFITM3 is associated with susceptibility to pediatric tuberculosis in Han Chinese population.
作者: Shen ChenWu Xi-rongJiao Wei-weiSun LinFeng Wei-xingXiao JingMiao QingLiu FangYin Qing-qinZhang Chen-guangGuo Ya-jieShen A-dong
作者单位: 1Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.
刊名: PloS one, 2013, Vol.8 (7), pp.e67816
来源数据库: PubMed Journal
DOI: 10.1371/journal.pone.0067816
原始语种摘要: A susceptibility locus for tuberculosis, a re-emerging infectious disease throughout the world, was previously discovered to exist on chromosome 11p15. IFITM3 gene encoding for interferon inducible transmembrane protein 3, is located at 11p15. It acts as an effector molecule for interferon-gamma, which is essential for anti-tuberculosis immune response. In order to investigate the association between susceptibility to TB and genetic polymorphisms of the IFITM3 core promoter, a case-control study including 368 TB patients and 794 healthy controls was performed in Han Chinese children in northern China. The rs3888188 polymorphism showed significant association with susceptibility to TB. The rs3888188 G allele, acting recessively, was more frequent in TB patients (95% confidence interval:...
全文获取路径: PubMed  (合作)
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来源刊物:
影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • susceptibility 磁化率
  • promoter 催化剂
  • tuberculosis 肺结核
  • pediatric 儿科的
  • polymorphism 多晶形
  • luciferase 荧光素酶
  • interferon 干扰素
  • functional 功能的
  • allele 等位基因
  • population 母体