Understanding the evolutionary relationship of hemagglutinin protein from influenza viruses using phylogenetic and molecular modeling studies.
作者: Karthikeyan MuthusamyKirubakaran PalaniSingh Kh DhanachandraSampath BhuvaneshwariKrishnasamy Gopinath
作者单位: 1a Department of Bioinformatics, Science Block , Alagappa University , Karaikudi , 630 004 , Tamil Nadu , India .
刊名: Journal of biomolecular structure & dynamics, 2014, Vol.32 (5), pp.816-30
来源数据库: PubMed Journal
DOI: 10.1080/07391102.2013.793211
原始语种摘要: The existing H1N1 (2009) swine flu is pandemic in nature and is responsible for global economic losses and fatalities. Among the eight gene segments of H1N1, hemagglutinin (HA) plays a major role in the attachment of the virus to the host cell surface and entry of viral RNA into the host cell leads to infection. In this study, sequence and phylogenetic analysis of the H1N1 (2009) HA, from Mexico City along with 1952 sequences, from different subtypes of pandemic influenza A virus were studied and results showed that the closest relationship of H1N1 (2009) Mexico strain was with the H1N1 (2007) Mallard Norway strain. Analysis of secondary structures predicted from the protein sequence revealed that diminishing of alpha helixes was observed in many areas of the sequences between the years...
全文获取路径: PubMed  (合作)
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关键词翻译
关键词翻译
  • hemagglutinin 血凝素
  • influenza 列性感冒
  • phylogenetic 门的
  • virus 病毒
  • pandemic 流行性的
  • protein 蛋白质
  • modeling 制祝型
  • relationship 关系
  • analysis 分析
  • sialic 硅铝质的