Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis.
作者: Hill K SErdogan EKhoor AWalsh M PLeitges MMurray N RFields A P
作者单位: 1Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
刊名: Oncogene, 2013
来源数据库: PubMed Journal
DOI: 10.1038/onc.2013.147
原始语种摘要: Protein kinase C alpha (PKCα) can activate both pro- and anti-tumorigenic signaling depending upon cellular context. Here, we investigated the role of PKCα in lung tumorigenesis in vivo. Gene expression data sets revealed that primary human non-small lung cancers (NSCLC) express significantly decreased PKCα levels, indicating that loss of PKCα expression is a recurrent event in NSCLC. We evaluated the functional relevance of PKCα loss during lung tumorigenesis in three murine lung adenocarcinoma models (LSL-Kras, LA2-Kras and urethane exposure). Genetic deletion of PKCα resulted in a significant increase in lung tumor number, size, burden and grade, bypass of oncogene-induced senescence, progression from adenoma to carcinoma and a significant decrease in survival in vivo. The tumor...
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影响因子:7.357 (2012)

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关键词翻译
关键词翻译
  • tumor 肿胀
  • adenocarcinoma 腺癌
  • significantly 较大地
  • kinase 激酶
  • activation 活化
  • survival 生存
  • enhanced 增强
  • suppressor 抑制栅
  • expression 表示
  • induced 感应的