Sepsis otopathy: experimental sepsis leads to significant hearing impairment due to apoptosis and glutamate excitotoxicity in murine cochlea.
作者: Schmutzhard JoachimGlueckert RudolfPritz ChristianBlumer Michael J FBitsche MarioLackner PeterFille ManfredRiechelmann HerbertHarkamp MatthiasSitthisak ThongrongSchrott-Fischer Annelies
作者单位: 1Department of Otorhinolaryngology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. Joachim.Schmutzhard@i-med.ac.at
刊名: Disease models & mechanisms, 2013, Vol.6 (3), pp.745-54
来源数据库: PubMed Journal
DOI: 10.1242/dmm.011205
原始语种摘要: Hearing loss is frequent in intensive care patients and can be due to several causes. However, sepsis has not been examined as a possible cause. The aim of this study is to assess the influence of experimental sepsis on hearing thresholds and to evaluate pathological changes in the cochlea. The cecal ligation puncture technique was used to induce sepsis in 18 mice. Results were compared with those from 13 sham-operated and 13 untreated control mice. The hearing thresholds of the animals were evaluated with auditory evoked brainstem responses prior to the induction of sepsis and again at the peak of the disease. Immediately after the second measurement, the mice were sacrificed and the inner ears harvested and prepared for further evaluation. The cochleae were examined with light...
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来源刊物:
影响因子:4.959 (2012)

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关键词翻译
关键词翻译
  • hearing 听觉
  • cochlea 耳蜗
  • otopathy 耳病
  • impairment 减损
  • sepsis 败血症
  • murine 鼠灰色
  • leads 引线
  • brainstem 脑干
  • auditory 听觉的
  • apoptosis 细胞死