NF-E2-Related Factor 2 Suppresses Intestinal Fibrosis by Inhibiting Reactive Oxygen Species-Dependent TGF-β1/SMADs Pathway.
作者: Guan YadiTan YueLiu WeiyuYang JunWang DongxuPan DiSun YanZheng Changqing
作者单位: 1Department of Gastroenterology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, China.
2Department of Gastroenterology, The People's Hospital Liaoning Provincial, 33 Wenyi Road, Shenhe District, Shenyang, 110013, Liaoning Province, China.
3Department of Gastroenterology, Shengjing Hospital of China Medical Universit
刊名: Digestive diseases and sciences, 2018, Vol.63 (2), pp.366-380
来源数据库: PubMed Journal
DOI: 10.1007/s10620-017-4710-z
关键词: ColitisFibrosisNF-E2-Related Factor 2Reactive oxygen speciesTGF-β1/SMADs signaling pathway
原始语种摘要: BACKGROUND AND AIMS(#br)This study aimed to evaluate the antifibrotic effects of NF-E2-Related Factor 2 (Nrf2) on intestinal fibrosis. Intestinal fibrosis is a common complication of Crohn's disease; however, its mechanism of intestinal fibrosis is largely unclear.(#br)METHODS(#br)BALB/c mice received 2,4,6-trinitrobenzene sulfonic acid weekly via intrarectal injections to induce chronic fibrotic colitis. They also diet containing received 1% (w/w) tert-butylhydroquinone (tBHQ), which is an agonist of Nrf2. Human intestinal fibroblasts (CCD-18Co cells) were pretreated with tBHQ or si-Nrf2 followed by stimulation with transforming growth factor-β1 (TGF-β1), which transformed the cells into myofibroblasts. The main fibrosis markers such as α-smooth muscle actin, collagen I, tissue inhibitor...
全文获取路径: PubMed  (合作)

  • fibrosis 纤维化
  • intestinal 肠的
  • suppressed 被抑制的
  • scavenging 扫气
  • inhibiting 抑制
  • diacetate 二醋酸盐
  • cells 麻风细胞
  • colitis 大肠炎
  • pathway 轨道
  • fibrotic 纤维变性的