|作者：||Jia Nan, Chen Yan, Tao Xiang, Ou Enzhi, Lu Xin, Feng Weiwei|
1Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 128 Shen Yang Road, Shanghai, 200090, People's Republic of China.
2Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease, Fudan University, 413 Zhao Zhou Road, Shanghai, 200011, People's Republic of China.
3Shanghai Gemple Biotech Co., Ltd, 2F, 3rd Building, Hengyue International Mansion, No.1238 Zhangjiang Road, Pudong New District, Shanghai, 201210, People's Republic of China.
4Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University, 128 Shen Yang Road, Shanghai, 200090, People's Republic of China.
5Shanghai Key Laboratory of Female Reproductive Endocrine-Related Di
|刊名：||Journal of ovarian research, 2017, Vol.10 (1), pp.46|
|关键词：||DNA polymorphic analysis; Gestational choriocarcinoma of the ovary;|
|原始语种摘要：||BACKGROUND(#br)Choriocarcinoma of the ovary is rare. This tumor can arise from gestational tissue or pure germ cells of the ovary, the former results in gestational choriocarcinoma. The clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary for effective treatment. One strategy for the differentiation of these tumors types is to identify the presence of paternal DNA by DNA polymorphic analysis.(#br)CASE PRESENTATION(#br)In the present case, a 27-year-old patient with a history of amenorrhea, lower abdominal pain and vaginal bleeding received a laparoscopic dissection of cystic mass of the right ovary according to an initial diagnosis of ectopic pregnancy. Primary choriocarcinoma of the ovary was diagnosed by pathology, but... its origin was uncertain. DNA polymorphic analysis was then performed and a gestational origin was confirmed. The patient subsequently exhibited an excellent response to chemotherapy, achieved complete remission and gave birth to a healthy baby.(#br)CONCLUSION(#br)Differentiation between two etiologies of primary choriocarcinoma can be achieved with DNA polymorphic analysis and it is necessary to distinguish between them to approach to an appropriate treatment of a patient.|