Vitamin U, a novel free radical scavenger, prevents lens injury in rats administered with valproic acid.
作者: Tunali SKahraman SYanardag R
作者单位: 1Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar, Istanbul, Turkey.
2Department of Food Engineering, Faculty of Engineering, Istanbul Aydin University, Kucukcekmece, Istanbul, Turkey.
3Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar, Istanbul, Turkey
刊名: Human & experimental toxicology, 2015, Vol.34 (9), pp.904-10
来源数据库: PubMed Journal
DOI: 10.1177/0960327114561665
关键词: Valproic acidLensRatVitamin U
原始语种摘要: Valproic acid (2-propyl-pentanoic acid, VPA) is the most widely prescribed antiepileptic drug due to its ability to treat a broad spectrum of seizure types. VPA exhibits various side effects such as organ toxicity, teratogenicity, and visual disturbances. S-Methylmethioninesulfonium is a derivative of the amino acid methionine and it is widely referred to as vitamin U (Vit U). This study was aimed to investigate the effects of Vit U on lens damage parameters of rats exposed to VPA. Female Sprague Dawley rats were divided into four groups. Group I comprised control animals. Group II included control rats supplemented with Vit U (50 mg/kg/day) for 15 days. Group III was given only VPA (500 mg/kg/day) for 15 days. Group IV was given VPA + Vit U (in same dose and time). Vit U was given to...
全文获取路径: PubMed  (合作)
影响因子:1.453 (2012)

  • scavenger 食腐动物
  • radical 
  • glutathione 谷胱甘肽
  • novel 长篇小说
  • peroxidation 过氧化
  • teratogenicity 致畸态性
  • reversed 倒转的
  • paraoxonase 二乙基对硝基苯磷酸酯酶
  • antioxidant 抗氧化剂
  • seizure 获得