Osteoblast conditioned media contain TGF-beta1 and modulate the migration of prostate tumor cells and their interactions with extracellular matrix components.
作者: Festuccia CBologna MGravina G LGuerra FAngelucci AVillanova IMillimaggi DTeti A
作者单位: 1Department of Experimental Medicine, Medical School, University of L'Aquila, Italy. festucci@univaq.it
刊名: International journal of cancer, 1999, Vol.81 (3), pp.395-403
来源数据库: PubMed Journal
原始语种摘要: Prostate cancers (PRCAs) frequently metastasize to bone. We show here that this process is facilitated by osteoblast-mediated tumor cell recruitment. Transforming growth factor-beta1 (TGF-beta1) is produced by osteoblasts in a latent form and is activated by proteases in a cell-dependent manner. This cytokine exhibits pleiotropic effects on cell-extracellular matrix (ECM) interactions and may influence tumor cell invasion and metastasis. Our purpose was to identify the potential molecular mechanisms involved in osteoblast-mediated cell recruitment and to characterize the effect of TGF-beta1 on adhesion, motility and invasiveness of a human prostate cancer cell line with high bone metastatic potential (PC3 cell line) in vitro. Conditioned media from osteoblast cultures (OB CM) enhanced PC3...
全文获取路径: PubMed  (合作)
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关键词翻译
关键词翻译
  • conditioned 经过调节的
  • extracellular 胞外的
  • modulate 
  • prostate 前列腺
  • components 零部件
  • osteoblast 成骨细胞
  • adhesion 粘附
  • pleiotropic 多向性的
  • potential 
  • tumor 肿胀