The in vitro hepatic metabolism of 1-phenyl-2-(2-benzothiazolinone-3-yl)ethanone and their reduced derivatives.
作者: Yilmaz FUlgen MDoğruer D SCakir BSahin M F
作者单位: 1University of Marmara, Department of Pharmaceutical Chemistry, Haydarpasa, Istanbul, Turkey.
刊名: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1999, Vol.51 (4-5), pp.442-5
来源数据库: PubMed Journal
原始语种摘要: The in vitro hepatic microsomal metabolism of 1-phenyl-2-(2-benzothiazolinone-3-yl)ethanone (I) and (+/-)-1-Phenyl-2-(2-benzothiazolinone-3-yl)ethanol (II) was studied using both rat microsomal preparations and soluble fractions fortified with NADPH. These two substrates and their potential dealkylation metabolite 2-benzothiazolinone were synthesized and their structures were elucidated by spectral methods. The results showed that (I) was metabolised to (II), the corresponding alcohol by reduction. More alcohol metabolite was observed with microsomes than those obtained with the soluble fractions. No dealkylation of (I) was observed in the experiments using both microsomes and soluble fractions. (II) was metabolised to (I), the corresponding ketone by oxidation. However, compared to the...
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影响因子:2.622 (2012)

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关键词翻译
关键词翻译
  • metabolite 蚀变粗玻岩
  • hepatic 肝的
  • reduced 减缩的
  • phenyl 苯基
  • dealkylation 脱烃酌
  • metabolism 代谢
  • observed 观察到的
  • soluble 可溶的
  • corresponding 对应的
  • NADPH 还原型烟酰胺腺嘌呤二核苷酸磷酸