Comparative study of testosterone and vitamin D analogue, elocalcitol, on insulin-controlled signal transduction pathway regulation in human skeletal muscle cells.
作者: Antinozzi CMarampon FSgrò PTombolini VLenzi ACrescioli CDi Luigi L
作者单位: 1Unit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135, Rome, Italy.
2Department of Radiotherapy, Sapienza University of Rome, Rome, Italy.
3Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
4Unit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135, Rome, Italy. clara.crescioli@uniroma4.it.
刊名: Journal of endocrinological investigation, 2019, Vol.42 (8), pp.897-907
来源数据库: PubMed Journal
DOI: 10.1007/s40618-018-0998-6
关键词: ElocalcitolHuman skeletal muscle cellsInsulinMetabolismTestosterone
原始语种摘要: PURPOSE(#br)Skeletal muscle (Skm) plays a key role in regulating energetic metabolism through glucose homeostasis. Several hormones such as Testosterone (T) and Vitamin D (VD) have been shown to affect energy-dependent cell trafficking by determining Insulin (I)-like effects.(#br)AIM(#br)To elucidate possible hormone-related differences on muscular metabolic control, we analyzed and compared the effects of T and elocalcitol (elo), a VD analogue, on the activation of energy-dependent cell trafficking, metabolism-related-signal transduction pathways and transcription of gene downstream targets.(#br)METHODS(#br)Human fetal skeletal muscle cells (Hfsmc) treated with T or elo were analyzed for GLUT4 localization, phosphorylation/activation status of AKT, ERK1/2, IRS-1 signaling and c-MYC...
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影响因子:1.654 (2012)

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关键词翻译
关键词翻译
  • muscle 肌肉
  • transduction 转导
  • skeletal 骨架
  • analogue 相似体
  • pathway 轨道
  • cells 麻风细胞
  • insulin 胰岛素
  • testosterone 睾酮
  • human 人的
  • translocation 移位