Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.
作者: Khoo Siew-KimRead JamesFranks KimberleyZhang GuichengBizzintino JoeleneColeman LauraMcCrae ChristopherÖberg LisaTroy Niamh MPrastanti FranciskaEverard JanetOo StephenBorland Meredith LMaciewicz Rose ALe Souëf Peter NLaing Ingrid ABosco Anthony
作者单位: 1Division of Cardiovascular and Respiratory Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
2Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.
3School of Public Health, Curtin University, Perth, Western Australia 6102, Australia.
4Centre for Genetic Origins of Health and Disease, The University of Western Australia, Perth, Western Australia 6009, Australia and Curtin University, Perth, Western Australia 6102, Australia.
5Division of Cardiovascular an
刊名: Journal of immunology (Baltimore, Md. : 1950), 2019
来源数据库: PubMed Journal
DOI: 10.4049/jimmunol.1800178
原始语种摘要: Asthma exacerbations are triggered by rhinovirus infections. We employed a systems biology approach to delineate upper-airway gene network patterns underlying asthma exacerbation phenotypes in children. Cluster analysis unveiled distinct IRF7hi versus IRF7lo molecular phenotypes, the former exhibiting robust upregulation of Th1/type I IFN responses and the latter an alternative signature marked by upregulation of cytokine and growth factor signaling and downregulation of IFN-γ. The two phenotypes also produced distinct clinical phenotypes. For IRF7lo children, symptom duration prior to hospital presentation was more than twice as long from initial symptoms ( p = 0.011) and nearly three times as long for cough ( p < 0.001), the odds ratio of admission to hospital was increased more than...
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关键词翻译
关键词翻译
  • delineate 描绘
  • distinct 相异的
  • presentation 提示
  • asthma 哮喘
  • Upper 上方
  • IRF Input Register Full
  • rhinovirus 鼻病毒
  • cytokine 细胞因子
  • exacerbation 恶化
  • twice 再次