BST2 promotes cell proliferation, migration and induces NF-κB activation in gastric cancer.
作者: Liu WeiyuCao YongGuan YadiZheng Changqing
作者单位: 1Department of Gastroenterology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang, 110022, People's Republic of China.
2Department of Gastroenterology, The People's Hospital of Liaoning Province, Shenyang, 110013, People's Republic of China.
3Department of Gastroenterology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang, 110022, People's Republic of China. zhengchangqing88@163.com.
刊名: Biotechnology letters, 2018
来源数据库: PubMed Journal
DOI: 10.1007/s10529-018-2562-z
关键词: ApoptosisBST2Gastric cancerNFκBProliferation
原始语种摘要: To investigate the functional roles of bone marrow stromal cell antigen 2 (BST2) in gastric cancer (GC) cells and its implications in the development of GC patients.;;BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demonstrated that knockdown of BST2 by siRNA inhibited cell proliferation, induced apoptosis and repressed cell motility in GC cells. In addition, the pro-tumor function of BST2 in GC was mediated partly through the NF-κB signaling.;;BST2 possesses the oncogenic potential in GC by regulating the proliferation, apoptosis, and migratory ability of GC cells, thereby BST2 could be a potential therapeutic target for the...
全文获取路径: PubMed  (合作)
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影响因子:1.853 (2012)

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关键词翻译
关键词翻译
  • BST BurST WAIT
  • gastric 胃的
  • knockdown 击倒
  • functional 功能的
  • demonstrated 探明的储量
  • investigate 
  • expression 表示
  • potential 
  • addition 添加
  • tumorous 肿的