|作者：||Liu Weiyu, Cao Yong, Guan Yadi, Zheng Changqing|
1Department of Gastroenterology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang, 110022, People's Republic of China.
2Department of Gastroenterology, The People's Hospital of Liaoning Province, Shenyang, 110013, People's Republic of China.
3Department of Gastroenterology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang, 110022, People's Republic of China. firstname.lastname@example.org.
|刊名：||Biotechnology letters, 2018, Vol.40 (7), pp.1015-1027|
|关键词：||Apoptosis; BST2; Gastric cancer; NFκB; Proliferation;|
|原始语种摘要：||OBJECTIVES(#br)To investigate the functional roles of bone marrow stromal cell antigen 2 (BST2) in gastric cancer (GC) cells and its implications in the development of GC patients.(#br)RESULTS(#br)BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demonstrated that knockdown of BST2 by siRNA inhibited cell proliferation, induced apoptosis and repressed cell motility in GC cells. In addition, the pro-tumor function of BST2 in GC was mediated partly through the NF-κB signaling.(#br)CONCLUSION(#br)BST2 possesses the oncogenic potential in GC by regulating the proliferation, apoptosis, and migratory ability of GC cells, thereby BST2... could be a potential therapeutic target for the treatment of GC.|