Radiation effects on male fertility.
作者: De Felice FMarchetti CMarampon FCascialli GMuzii LTombolini V
作者单位: 1Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
2Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
3Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L'Aquila, L'Aquila, Italy.
刊名: Andrology, 2019, Vol.7 (1), pp.2-7
来源数据库: PubMed Journal
DOI: 10.1111/andr.12562
关键词: FertilityLate effectsOligospermiaRadiationRadiotherapySpermatogenesisSpermatogonia
原始语种摘要: BACKGROUND(#br)Spermatogenesis is a process of dynamic cell differentiation. Ionizing radiation impairs spermatogenesis, and spermatogonia are more radiosensitive than spermatocytes or spermatids. Consistent with this assumption and due to improvement in tumor curability, nowadays, fertility preservation represents a public health need.(#br)OBJECTIVES(#br)To discuss radiotherapy-induced risk to male fertility and raise oncologic awareness of male fertility in daily clinical practice.(#br)MATERIALS AND METHODS(#br)PubMed and Clinicaltrials.gov databases were searched for papers in English.(#br)RESULTS(#br)We provide an overview of clinical landscape. Four main issues were proposed: (i) spermatogenesis and radiobiological general concepts; (ii) impairment of spermatogenesis; (iii)...
全文获取路径: PubMed  (合作)

  • fertility 肥度
  • impairment 减损
  • radiosensitive 放射敏感的
  • radiotherapy 放射线疗法
  • improvement 改良
  • daily 每天的
  • spermatogonia 精原细胞
  • nowadays 现今
  • radiation 辐射
  • discuss 议论