1-Deoxy-sphingolipids.
作者: Lone M ASantos TAlecu ISilva L CHornemann T
作者单位: 1Institute for Clinical Chemistry, University Hospital Zurich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland.
2Institute for Clinical Chemistry, University Hospital Zurich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland; iMed.ULisboa - Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal; Centro de Química-Física Molecular and IN-Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
3Neural Regeneration Laboratory, India Taylor Lipidomic Research Platform, Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Ottawa Brain and Mind Research Institute, University of Ottawa, Canada.
4iMed.ULisboa - Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal; Cent
刊名: Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019
来源数据库: PubMed Journal
DOI: 10.1016/j.bbalip.2018.12.013
关键词: AlanineAtypical sphingolipidsGlycineHSAN1SerineSphingolipid metabolismT2DM
原始语种摘要: Sphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently, 1-deoxysphingolipids cannot be converted to complex sphingolipids and not degraded over the canonical catabolic pathways. Pathologically elevated 1-deoxySLs are involved in several diseases. Within this review, we will provide an up-to-date overview on the metabolic, physiological and pathophysiological aspects of this enigmatic class of "headless" sphingolipids.
全文获取路径: PubMed  (合作)
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关键词翻译
关键词翻译
  • eukaryotic 真核的
  • several 各自
  • enigmatic 谜的
  • canonical 标准的
  • structurally 在结构上
  • catabolic 分解代谢的
  • fundamental 基本的
  • involved 涉及
  • headless 无头的
  • complex 超群