[Preparation and quality evaluation of Iohexol liposomes].
作者: Zhou RongliZhu XialiHung GuihuaZhang NaZhang Bingjie
作者单位: 1School of Phamacy, Shandong University, Jinan 250012, China.
刊名: Shengwu Yixue Gongchengxue Zazhi, 2007, Vol.24 (4), pp.918-22
来源数据库: PubMed Journal
原始语种摘要: The liposomes were prepared by reverse-phase evaporation technique. The morphology of the liposomes, the entrapment efficiency and the particle size distribution were evaluated. The CT signals of Iohexol liposomes in rabbits were compared with those of Iohexol injection in rabbits. The entrapment efficiency of Iohexol liposomes was 82.35% +/- 1.82%. The liposmes were spherical or ellipsoidal shape in shape. The mean diameter of the Iohexol liposomes was 207 7 nm. The polydispersity index was 0.355. The Zeta potential was--1.83 mV. The drug was highly entrapped into the liposomes with good reproduction and stability. The in vitro release of Iohexol liposomes was significantly slower than that of Iohexol,and was 98.57% at 24 h. Iohexol liposomes may reduce the dosage, prolong the effective...
全文获取路径: PubMed  (合作)
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关键词翻译
关键词翻译
  • entrapment 诱陷
  • developing 显影
  • prolong 拉长
  • polydispersity 多分散性
  • reduce 减少
  • shape 形状
  • efficiency 效率
  • particle 颗粒
  • morphology 形态学
  • evaporation 蒸发