Protective effects of metformin treatment on the liver injury of streptozotocin-diabetic rats.
作者: Yanardag ROzsoy-Sacan OBolkent SOrak HKarabulut-Bulan O
作者单位: 1Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar, Istanbul, Turkey.
刊名: Human & Experimental Toxicology, 2005, Vol.24 (3), pp.129-35
来源数据库: PubMed Journal
原始语种摘要: Metformin is a biguanide derivate used as an oral hypoglycaemic drug in diabetics. The aim of this study was to examine the histological and biochemical effects of metformin in streptozotocin (STZ)-treated rats. The animals were rendered diabetic by intraperitoneal injection of 65 mg/kg STZ. Fourteen days later, metformin was given at 25 mg/kg by gavage, daily for 28 days, to STZ-diabetic rats and a control group. In the STZ-diabetic group, some degenerative changes were observed by light microscopic examination. But the degenerative changes were decreased in the STZ-diabetic group given metformin. In the STZ-diabetic group, blood glucose levels, serum alanine and aspartate transaminase (ALT and AST) activities, total lipid levels, and sodium and potassium levels increased, while body...
全文获取路径: PubMed  (合作)
影响因子:1.453 (2012)

  • metformin 二甲双胍
  • diabetic 糖尿病患者
  • streptozotocin 链脲佐菌素
  • liver 
  • degenerative 退化的
  • glucose 葡萄糖
  • diabetes 糖尿病
  • biguanide 双胍
  • potassium 
  • derivate 衍生物