Gestational choriocarcinoma of the ovary diagnosed by analysis of tumour DNA.
作者: Lorigan P CGrierson A JGoepel J RColeman R EGoyns M H
作者单位: 1YCRC Department of Clinical Oncology, Weston Park Hospital, Sheffield, UK.
刊名: Cancer letters, 1996, Vol.104 (1), pp.27-30
来源数据库: PubMed Journal
原始语种摘要: Gestational choriocarcinoma of the ovary is a rare form of malignancy which can be difficult to distinguish from primary ovarian choriocarcinoma. The ability to make such a diagnosis could, however, have important implications for therapy. We report here a case of choriocarcinoma whose origins were difficult to determine and which behaved clinically more like a primary rather than a gestational choriocarcinoma. We have analysed DNA from this tumour by using polymerase chain reaction (PCR) amplification of a range of polymorphic alleles and have demonstrated that the tumour was in fact gestational. Furthermore, the lack of chromosome Y sequences and the presence of heterozygosity of the spouse's alleles, indicated that this tumour arose as a result of dispermic fertilisation of an empty...
全文获取路径: PubMed  (合作)
影响因子:4.258 (2012)

  • tumour 肿瘤
  • ovary 子房
  • dispermic 具双种子的
  • gestational 妊娠期的
  • fertilisation 受精
  • ovarian 卵巢的
  • malignancy 恶性
  • alleles 对立形质
  • chromosome 染色体
  • demonstrated 探明的储量