Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis.
作者: Zhuo ChuanjunXu YongLiu ShaLi JingZheng QishiGao XiangyangLi ShenJing RixingSong XueqinYue WeihuaZhou ChunhuaUpthegrove Rachel
作者单位: 1Department of Psychiatry and Morbidity, Tianjin Anding Hospital, Tianjin Medical University, Tianjin, China.
2Department of Psychiatry, Jining Medical University, Jining, China.
3Department of Psychiatry, Tianjin Medical University, Tianjin, China.
4Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China.
5MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan, China.
6Department of Neurobiology, National Key Disciplines, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, China.
7Department of Neurobiology, National Key Disciplines, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical U
刊名: Frontiers in pharmacology, 2018, Vol.9 , pp.1393
来源数据库: PubMed Journal
DOI: 10.3389/fphar.2018.01393
关键词: Antipsychotic-induced weight gainMetforminNetwork meta-analysisPharmacological add-onsTopiramate
原始语种摘要: Background: Antipsychotic drugs may lead to side effects such as obesity, diabetes, dyslipidemia, and cardiovascular disease. The current systematic review and network meta-analysis analyzes and provides an update on the clinical performance of these add-ons in comparison to placebo on body weight and body mass index (BMI) reductions. Methods: A comprehensive literature search was performed on electronic databases: PubMed (1946-), Embase (1974-), Cochrane library (1992-), and OpenGrey (2000-) until 31 July 2018. Network meta-analyses, comparing the body weight change, BMI change and withdrawn due to adverse events of different pharmacological add-ons, was performed using a multivariate meta-regression model with random-effects, adopting a frequentist approach. To rank the prognosis for...
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关键词翻译
关键词翻译
  • antipsychotic 抗精神病的
  • comparing 比较
  • weight 
  • diabetes 糖尿病
  • induced 感应的
  • change 变化
  • effectiveness 有效性
  • adverse 逆的
  • analysis 分析
  • significantly 较大地