Effect of heat-killed Streptococcus thermophilus on type 2 diabetes rats.
作者: Gao XiangyangWang FeiZhao PengZhang RongZeng Qiang
作者单位: 1Health Management Institute, The Second Medical Center of Chinese PLA General Hospital, Beijing, China.
2Health Management Center, HangZhou Special Service Convalescent Center of Air Force, PLA, Hangzhou, China.
刊名: PeerJ, 2019, Vol.7 , pp.e7117
来源数据库: PubMed Journal
DOI: 10.7717/peerj.7117
关键词: DiabetesGut microbiotaHeat-killed Streptococcus thermophilusZDF rats
原始语种摘要: Background and Aims(#br)The link between gut microbiota and type 2 diabetes (T2D) has been addressed by numerous studies. Streptococcus thermophilus from fermented milk products, has been used as a probiotic in previous research. However, whether heat-killed S. thermophilus can improve the glycemic parameters of diabetic rats remains unanswered. In this study, we evaluated the effect of heat-killed S. thermophilus on T2D model rats and the potential mechanisms of the effect.(#br)Methods(#br)Zucker diabetic fatty (ZDF) rats were used to generate a diabetic rat model induced by feeding a high-fat diet. Heat-killed S. thermophilus were orally administered to normal and diabetic rats for 12 weeks. Intestinal microbiota analysis, histology analysis, oral glucose tolerance test and measurement...
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关键词翻译
关键词翻译
  • killed 脱氧的
  • microbiota 微生物区系
  • diabetes 糖尿病
  • effectively 有效地
  • diabetic 糖尿病患者
  • interleukin 白细胞间介素
  • intestinal 肠的
  • glucose 葡萄糖
  • intolerance 不耐性
  • remains 残渣