Immune check-point in glioblastoma multiforme.
作者: De Felice FPranno NMarampon FMusio DSalducci MPolimeni ATombolini V
作者单位: 1Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy. Electronic address: fradefelice@hotmail.it.
2Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy.
3Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
4Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
刊名: Critical reviews in oncology/hematology, 2019, Vol.138 , pp.60-69
来源数据库: PubMed Journal
DOI: 10.1016/j.critrevonc.2019.03.019
关键词: BenefitGlioblastomaImmune check-pointImmunotherapySurvival
原始语种摘要: Glioblastoma multiforme (GBM) represents one of the main frequent and aggressive primary brain neoplasms among adults worldwide. Despite a first-line multimodal treatment, including radical surgery and adjuvant radiation therapy with concomitant temozolomide-based chemotherapy, GBM prognosis continues to be unfavourable. During this decade, different research groups have explored immune check-point inhibitors role in order to improve response to therapy and subsequently prolong survival rate. The aim of this review was to analyze published literature to support immune check-point inhibitors use in the management of patients with GBM diagnosis. The hope was to help physicians for better decision-making.
全文获取路径: PubMed  (合作)
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影响因子:4.637 (2012)

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关键词翻译
关键词翻译
  • check 检查
  • point 
  • immune 免疫的
  • frequent 时常的
  • multimodal 多峰
  • glioblastoma 成胶质细胞瘤
  • chemotherapy 化学疗法
  • decision 决定
  • support 支柱
  • aggressive 侵蚀的