Lack of synergistic interaction between quercetin and catechin in systemic and pulmonary vascular smooth muscle.
作者: Menendez CarmenJimenez RosarioMoreno LauraGalindo PilarCogolludo AngelDuarte JuanPerez-Vizcaino Francisco
作者单位: 1Department of Pharmacology, School of Medicine, University Complutense of Madrid, Madrid, Spain.
刊名: The British journal of nutrition, 2011, Vol.105 (9), pp.1287-93
来源数据库: PubMed Journal
DOI: 10.1017/S0007114510004952
原始语种摘要: Due to their ubiquitous distribution, flavonoids from different classes are commonly present together in foods. However, little is known about the interactions between them. The flavonol quercetin and the flavan-3-ol (+)-catechin are among the most abundant flavonoids in the diet. In the present study, we have analysed the interactions between these two flavonoids on vascular function using two pure compounds and mixtures of these flavonoids in 1:0·1, 1:1 or 1:10 proportions. Quercetin induced a more potent concentration-dependent relaxant effect than catechin in the isolated rat aorta, and the isobolographic analysis of the mixtures showed no synergistic or antagonistic effects between them, i.e. their effects were additive. Quercetin was more potent in mesenteric than in pulmonary...
全文获取路径: PubMed  (合作)
影响因子:3.302 (2012)

  • catechin 八茶酸
  • quercetin 槲皮苷
  • synergistic 协同的
  • vascular 维管的
  • flavonoids 黄酮类似物
  • pulmonary 肺的
  • effect 效应
  • flavonol 黄酮醇
  • muscle 肌肉
  • flavan 黄烷杀