Expression of TMEM40 in bladder cancer and its correlation with clinicopathological parameters.
作者: Zhang Qing-YanFu Mei-TingZhang Zhen-FeiFeng Yu-ZhenWei MinZhou Jue-YuShi Rong
作者单位: 1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China.
2The First School of Clinical Medicine, Southern Medical University Guangzhou, China.
3Department of Biochemistry and Molecular Biology, School of Basic
刊名: International journal of clinical and experimental pathology, 2017, Vol.10 (7), pp.8050-8057
来源数据库: PubMed Journal
关键词: TMEM40Bladder cancerClinicopathological parametersDiagnostic biomarkerTissue microarray
原始语种摘要: Transmembrane protein 40 (TMEM40) is a 23-kDa protein in cell membrane. There is no report that TMEM40 is associated with cancer. However, our study found that TMEM40 was high expressed in bladder cancer tissues. Immunohistochemical analyses of TMEM40 expression were performed on a tissue microarray including 72 transitional cell carcinomas and 43 normal bladder tissues to investigate the expression and clinical significance of TMEM40 in bladder cancer. We adopted receiver operating characteristic (ROC) analysis to select the optimal cut-off score. TMEM40 expression was defined positive if above 62.5% of cells were stained, and below it was negative. Then, the expression of TMEM40 in bladder cancer cells was evaluated by quantitative real-time PCR and western blot analysis. A...
全文获取路径: PubMed  (合作)
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关键词翻译
关键词翻译
  • bladder 膀胱
  • cancer 癌症
  • transitional 过渡的
  • parameters 参数
  • expression 表示
  • protein 蛋白质
  • associated 相关的
  • biomarker 生物标志化合物
  • normal 法线
  • significantly 较大地