Serum level of co-expressed hub miRNAs as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
作者: Su QiangZhu Emily CQu Yao-LongWang Di-YaQu Wei-WeiZhang Chen-GuangWu TingGao Zu-Hua
作者单位: 1Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
2Desautels Faculty of Management, McGill University, Montreal, Quebec, H3A 1G5, Canada.
3Schulich School of Music, McGill University, Montreal, Quebec, H3A 1E3, Canada.
4Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center, Montreal, Quebec, H2X0A9, Canada.
5State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
6Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
7Department of Mathematics, Nanjing University, 210023, China.
8Department of Pathology, Research Institute of McGill University Health Center, Montreal, Quebec, H4A 3J1, Canada.
刊名: Journal of Cancer, 2018, Vol.9 (21), pp.3991-3999
来源数据库: PubMed Journal
DOI: 10.7150/jca.27697
关键词: Hub miRNAsMiRNAsPancreatic ductal adenocarcinoma
原始语种摘要: Background: Sensitive and specific non-invasive biomarkers are urgently needed in order to improve the survival of patients with pancreatic ductal adenocarcinoma (PDAC), which is the fourth leading cause of cancer-related death. We aim to identify serum hub miRNAs as potential diagnostic and prognostic biomarkers for PDAC. Methods: A total of 2578 serum miRNA expression data from 88 PDAC patients and 19 healthy subjects were downloaded from the Gene Expression Omnibus database. Weighted gene co-expression network analysis (WGCNA) was constructed and significant modules were extracted from the network by WGCNA R package. Network modules and hub miRNAs closely related to PDAC were identified. The prognostic value of hub miRNAs was assessed by Kaplan-Meier overall survival analysis. Results:...
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关键词翻译
关键词翻译
  • ductal 管的
  • adenocarcinoma 腺癌
  • pancreatic 胰的
  • diagnostic 诊断的
  • prognostic 预测的
  • expressed 榨出的
  • survival 生存
  • potential 
  • tumorigenesis 瘤形成
  • turquoise 绿松石