Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage.
作者: Marampon FGravina G LJu XVetuschi ASferra RCasimiro M CPompili SFestuccia CColapietro AGaudio EDi Cesare ETombolini VPestell R G
作者单位: 1University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, Italy.
2Department of Cancer Biology, Medical Oncology and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
3Department of Human Anatomy, "La Sapienza" University of Rome, Rome, Italy.
4Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
刊名: Oncotarget, 2016, Vol.7 (5), pp.5383-400
来源数据库: PubMed Journal
DOI: 10.18632/oncotarget.6579
关键词: DNA double-strand break repairNHEJcyclin D1prostate cancerradiotherapy
原始语种摘要: Patients with hormone-resistant prostate cancer (PCa) have higher biochemical failure rates following radiation therapy (RT). Cyclin D1 deregulated expression in PCa is associated with a more aggressive disease: however its role in radioresistance has not been determined. Cyclin D1 levels in the androgen-independent PC3 and 22Rv1 PCa cells were stably inhibited by infecting with cyclin D1-shRNA. Tumorigenicity and radiosensitivity were investigated using in vitro and in vivo experimental assays. Cyclin D1 silencing interfered with PCa oncogenic phenotype by inducing growth arrest in the G1 phase of cell cycle and reducing soft agar colony formation, migration, invasion in vitro and tumor formation and neo-angiogenesis in vivo. Depletion of cyclin D1 significantly radiosensitizes PCa cells...
全文获取路径: PubMed  (合作)
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影响因子:6.636 (2012)

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关键词翻译
关键词翻译
  • strand 海滨
  • cells 麻风细胞
  • silencing 消声
  • prostate 前列腺
  • resistant 耐久的
  • androgen 雄激素
  • tumorigenicity 致肿瘤性
  • cyclin 细胞周期蛋白
  • cancer 癌症
  • damage 损伤