The PD-L1/CD86 ratio is increased in dendritic cells co-infected with porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus, and the PD-L1/PD-1 axis is associated with anergy, apoptosis, and the induction of regulatory T-cells in porcine lymphocytes.
作者: Richmond OCecere T EErdogan EMeng X JPiñeyro PSubramaniam STodd S MLeRoith T
作者单位: 1Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA, United States.
2Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA, United States. Electronic address: tcecere@vt.edu.
刊名: Veterinary microbiology, 2015, Vol.180 (3-4), pp.223-9
来源数据库: PubMed Journal
DOI: 10.1016/j.vetmic.2015.09.014
关键词: Co-infectionMonocyte derived dendritic cells (MoDC)Porcine circovirus associated disease (PCVAD)Porcine circovirus type 2 (PCV2)Porcine reproductive and respiratory syndrome virus (PRRSV)Programed cell death-1 (PD-1)Programed death ligand-1 (PD-L1)
原始语种摘要: Porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) continue to have a negative economic impact on global swine production operations. Host immune modulations that potentiate disease during PCV2 and/or PRRSV infections are important areas of ongoing research. In this study, we evaluated the expression levels of PD-L1, CD86, and IL-10 in order to phenotype dendritic cells following viral infection with PCV2b and/or PRRSV. The results showed that the inhibitory marker PD-L1 was significantly increased in monocyte derived dendritic cells (MoDC) in both singular PCV2 infection and PCV2/PRRSV co-infections. MoDC expression of stimulatory marker CD86 was significantly increased during singular PCV2 infections, while it was significantly decreased in...
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影响因子:3.127 (2012)

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关键词翻译
关键词翻译
  • dendritic 师状的
  • regulatory 控制的
  • anergy 
  • apoptosis 细胞死
  • cells 麻风细胞
  • infected 被感染
  • lymphocyte 淋巴细胞
  • increased 增加
  • anergic 无变应性的
  • porcine 猪的