Cohousing Male Mice with and without Segmental Bone Defects.
作者: Rytlewski Jeffrey DChildress Paul JScofield David CKhan FaisalAlvarez Marta BTucker Aamir THarris Jonathan SPeveler Jessica LHickman Debra LChu Tien-Min GKacena Melissa A
作者单位: 1Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
2Laboratory Animal Resource Center, Indiana University School of Medicine, Indianapolis, Indiana.
3Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, Indiana.
4Department of Orthopaedic Surge
刊名: Comparative medicine, 2019, Vol.68 (2), pp.131-138
来源数据库: PubMed Journal
原始语种摘要: Spaceflight results in bone loss like that associated with osteoporosis or decreased weight-bearing (for example, high-energy trauma such as explosive injuries and automobile accidents). Thus, the unique spaceflight laboratory on the International Space Station presents the opportunity to test bone healing agents during weightlessness. We are collaborating with NASA and the US Army to study bone healing in spaceflight. Given the unique constraints of spaceflight, study design optimization was required. Male mice were selected primarily because their femur is larger than females', allowing for more reproducible surgical outcomes. However, concern was raised regarding male mouse aggression. In addition, the original spaceflight study design included cohousing nonoperated control mice with...
全文获取路径: PubMed  (合作)
影响因子:1.12 (2012)

  • spaceflight 航天
  • weightlessness 无重力
  • aggressive 侵蚀的
  • laboratory 实验室
  • operated 被操作的
  • preoperative 操作前的
  • osteoporosis 骨质疏松
  • anesthetic 麻醉剂
  • analgesic 镇痛药
  • vulnerable 要害