Longitudinal Anthropometric Assessment of Rhesus Macaque ( Macaca mulatta ) Model of Huntington Disease.
作者: Hunter Carissa EPongos Alvince LChi Tim YPayne ChristaStroud Fawn CChan Anthony W S
作者单位: 1Division of Neuropharmacology and Neurologic Diseases, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia.
2Division of Neuropharmacology and Neurologic Diseases, Emory University School of Medicine, Atlanta, Georgia.
3Marcus Autism Center, Children's Healthcare of Atlanta, Department of Pediatrics, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia.
4Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia.
5Division of Neuropharmacology and Neurologic Diseases, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia;, Email: awchan@emory.edu.
刊名: Comparative medicine, 2019, Vol.68 (2), pp.163-167
来源数据库: PubMed Journal
原始语种摘要: The neurodegeneration associated with Huntington disease (HD) leads to the onset of motor and cognitive impairment and their advancement with increased age in humans. In children at risk for HD, body measurement growth abnormalities include a reduction in BMI, weight, height, and head circumference. The transgenic HD NHP model was first reported in 2008, and progressive decline in cognitive behaviors and motor impairment have been reported. This study focuses on longitudinal body measurements in HD macaques from infancy through adulthood. The growth of HD macaques was assessed through head circumference, sagittal and transverse head, and crown-to-rump ('height') measurements and BMI. The animals were measured monthly from 0 to 72 mo of age and every 3 mo from 72 mo of age onward. A...
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影响因子:1.12 (2012)

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关键词翻译
关键词翻译
  • circumference 圆周
  • impairment 减损
  • associated 相关的
  • physiologic 生理的
  • increased 增加
  • growth 生长
  • translational 平移的
  • controls 控制机构
  • cognitive 修]认知[识
  • comparability 可比性