Vesicle-associated urokinase plasminogen activator promotes invasion in prostate cancer cell lines.
作者: Angelucci AD'Ascenzo SFestuccia CGravina G LBologna MDolo VPavan A
作者单位: 1Department of Experimental Medicine, University of L'Aquila, Italy.
刊名: Clinical & experimental metastasis, 2000, Vol.18 (2), pp.163-70
来源数据库: PubMed Journal
原始语种摘要: The ability of a cell to modify the extracellular matrix is important in several pathophysiological alterations including tumorigenesis. Cell transformation is accompanied by changes in the surrounding stroma as a result of the action of specific proteases such as the urokinase plasminogen activator (uPA), which has been associated with invasive potential in many tumor types. In this study, we analyzed the release of vesicle-associated uPA by the aggressive prostatic carcinoma cell line PC3 and the implications of this release for the invasive behaviour of prostatic tumor cells. Zymography and Western blot analysis revealed the presence of vesicle-associated uPA in the high-molecular weight form. Vesicles adhered to and degraded both collagen IV and reconstituted basal membrane...
全文获取路径: PubMed  (合作)
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来源刊物:
影响因子:3.46 (2012)

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关键词翻译
关键词翻译
  • plasminogen 胞浆素原
  • associated 相关的
  • prostate 前列腺
  • urokinase 尿激酶
  • activator 活化剂
  • prostatic 前列腺的
  • invasion 侵入
  • invasive 侵入的
  • cancer 癌症
  • tumorigenesis 瘤形成