Allele and genotype frequency of MDR1 C3435T in Tamilian population.
作者: Ramasamy KesavanSisy Sam SoyaChandrasekaran Adithan
作者单位: 1Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry, India.
刊名: Drug metabolism and pharmacokinetics, 2006, Vol.21 (6), pp.506-8
来源数据库: PubMed Journal
原始语种摘要: The allele and genotype frequencies of MDR1 C3435T polymorphism were determined in 185 unrelated healthy Tamilians. The genomic DNA was extracted from peripheral leucocytes using phenol chloroform method and genotyped by PCR-RFLP method. The frequencies of MDR1 C3435 and T3435 alleles in Tamilian population were 0.46 and 0.54 respectively. The distribution of T3435 in this population was found to be greater than Africans and almost similar to Caucasians and Orientals. The distribution of CC, CT and TT genotypes was 0.18, 0.56 and 0.26 respectively. The frequency distribution of the CC genotype was lower in them when compared with Chinese and Africans whereas CT genotype was higher in comparison with all the major ethnic groups.
全文获取路径: PubMed  (合作)
影响因子:2.071 (2012)

  • population 母体
  • genotype 属型
  • alleles 对立形质
  • whereas 鉴于
  • genomic 染色体组的
  • polymorphism 多晶形
  • respectively 分别
  • major 知的
  • distribution 分布
  • chloroform 氯仿